Genome-wide identifications of regulatory variants influencing milk fat percentage in Chinese Holstein cow
Changliang Gong, Yaran Zhang, Chunhong Yang, Zhihua Ju, Wenhao Liu, Qiang Jiang, Xiuge Wang, Yao Xiao, Xiaochao Wei, Yaping Gao, Lingling Wang, Yundong Gao, Jinpeng Wang, Jinming Huang · 2025
Read Genome-wide identifications of regulatory variants influencing milk fat percentage in Chinese Holstein cow by Changliang Gong, Yaran Zhang, Chunhong Yang, Zhihua Ju, Wenhao Liu, Qiang Jiang, Xiuge Wang, Yao Xiao, Xiaochao Wei, Yaping Gao, Lingling Wang, Yundong Gao, Jinpeng Wang, Jinming Huang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12849735.txt.
Description
Changliang Gong and co-authors hunt for gene variants that steer how much fat ends up in cow's milk. Their 2025 study scans the full genome of 2,709 Chinese Holstein cows, using breeding value estimates for milk fat share as the trait under study.
The scan found one hundred four strong variant sites, with a dense cluster in a gene region long tied to fat output. Eight sites sat inside genes, and four changed the protein code in ways predicted to steady the proteins. A check in a second herd confirmed three sites between genes, and lab tests showed one of them changes how a key fat-making switch binds. The findings offer targets for breeding cows with richer milk.
Catalog record
| CREATOR | Changliang Gong, Yaran Zhang, Chunhong Yang, Zhihua Ju, Wenhao Liu, Qiang Jiang, Xiuge Wang, Yao Xiao, Xiaochao Wei, Yaping Gao, Lingling Wang, Yundong Gao, Jinpeng Wang, Jinming Huang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |