Reactive oxygen species-associated molecular landscape uncovers diagnostic and immune features in osteoarthritis
Jiawei Zhou, Ping Qiu, Tianyu Liang, Binger Xue · 2025
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Description
Jiawei Zhou and co-authors map genes tied to oxidative stress in osteoarthritis in a 2025 study. The joint disease wears down cartilage with swelling and breakdown. Reactive oxygen species are thought to drive part of the harm, but the gene paths linking them to immune activity were murky.
Blending public gene data sets, the team built a seven-gene risk score with strong diagnostic accuracy. The score rose with inflammation signals and with immune cell presence in joint tissue. Rat and cell tests confirmed that a bacterial trigger raises oxygen stress and cell movement. Readers get candidate markers and targets for joint drugs aimed at oxygen stress.
Catalog record
| CREATOR | Jiawei Zhou, Ping Qiu, Tianyu Liang, Binger Xue |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |