Shared but distinct functional connectome profiles underlying rumination in depressed and healthy individuals
Xiao Chen, Feng-Nan Jia, Fei-Yi Liu, Yan-Song Liu, Xun Liu, Chao-Gan Yan · 2025
Read Shared but distinct functional connectome profiles underlying rumination in depressed and healthy individuals by Xiao Chen, Feng-Nan Jia, Fei-Yi Liu, Yan-Song Liu, Xun Liu, Chao-Gan Yan (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12849639.txt.
Description
Xiao Chen and five colleagues published a brain imaging study in two thousand twenty-five on rumination, the repetitive dwelling on negative thoughts. Rumination feeds depression's onset and return. Past work mostly scanned resting brains or relied on self-report, missing the active state.
Forty-three depressed patients and forty-two matched controls underwent scans while a task induced rumination or distraction. Both groups strengthened links inside the default mode network while ruminating. Controls additionally boosted attention network links, which patients lacked. One attention hub grew more central in patients only, scaling with symptom severity. The authors describe a shared core circuit plus a patient-specific attention twist.
Catalog record
| CREATOR | Xiao Chen, Feng-Nan Jia, Fei-Yi Liu, Yan-Song Liu, Xun Liu, Chao-Gan Yan |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |