Integrated transcriptome study reveals a stress response state CD4 +T cells related to immune tolerance in breast cancer
Jinyuan Gu, Qi Qi, Xinrui Mao, Rong Cong, Yue Sun, Xinyu Tang, Xiaoxiang Guan, Ji Wang, Muxin Yu, Shui Wang, Hong Pan, Kai Zhang, Wen Qiu, Wei Li, Cong Wang, Wenbin Zhou · 2025
Read Integrated transcriptome study reveals a stress response state CD4 +T cells related to immune tolerance in breast cancer by Jinyuan Gu, Qi Qi, Xinrui Mao, Rong Cong, Yue Sun, Xinyu Tang, Xiaoxiang Guan, Ji Wang, Muxin Yu, Shui Wang, Hong Pan, Kai Zhang, Wen Qiu, Wei Li, Cong Wang, Wenbin Zhou (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12849589.txt.
Description
Jinyuan Gu and fifteen co-authors profiled immune cells in breast cancer and its lymph nodes in 2025 at single-cell resolution. Lymph nodes are where anti-tumor immunity is built, yet their state before and after spread was unclear. The team analyzed sixty-seven samples and confirmed key patterns in thirteen more patients with lab methods.
Uninvolved nodes looked alike across patients, while nodes with spread varied by cancer subtype. In one subtype, a stressed class of helper T cells stood out and linked to immune tolerance. That cell state may explain why some spread nodes fail to fight back.
Catalog record
| CREATOR | Jinyuan Gu, Qi Qi, Xinrui Mao, Rong Cong, Yue Sun, Xinyu Tang, Xiaoxiang Guan, Ji Wang, Muxin Yu, Shui Wang, Hong Pan, Kai Zhang, Wen Qiu, Wei Li, Cong Wang, Wenbin Zhou |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |