Elevated prolactin and association with treatment resistance indicators in first-hospitalized schizophrenia spectrum disorders: a real-world cohort study
Dan Qi, Wenjie Sun, Meijuan Li, Tongxin Li, Jing Ma, Di Liu, Minghui Li, Chenghao Lu, Xinxu Wang, Yeqing Dong, Shaobing Li, Yanzhe Li, Jie Li, Shen Li, Nannan Liu · 2025
Read Elevated prolactin and association with treatment resistance indicators in first-hospitalized schizophrenia spectrum disorders: a real-world cohort study by Dan Qi, Wenjie Sun, Meijuan Li, Tongxin Li, Jing Ma, Di Liu, Minghui Li, Chenghao Lu, Xinxu Wang, Yeqing Dong, Shaobing Li, Yanzhe Li, Jie Li, Shen Li, Nannan Liu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12849556.txt.
Description
Dan Qi and co-authors examine whether high prolactin marks treatment resistance in first-episode schizophrenia care, in a 2025 study. Prolactin, a hormone, often rises on antipsychotic drugs, but it can be high before treatment too. Whether it signals a harder-to-treat illness was underexplored in real-world data.
The cohort held over four thousand patients at their first hospitalization for a schizophrenia spectrum disorder. Elevated prolactin was commonest in women aged eighteen to forty-five, affecting over seventy percent. In men, higher prolactin oddly accompanied less use of clozapine, the last-resort drug that marks resistance, and users had lower levels than non-users. Statistical curves tested how well the hormone discriminates clozapine use. The sex-dependent twist warns against reading one hormone as a universal resistance flag.
Catalog record
| CREATOR | Dan Qi, Wenjie Sun, Meijuan Li, Tongxin Li, Jing Ma, Di Liu, Minghui Li, Chenghao Lu, Xinxu Wang, Yeqing Dong, Shaobing Li, Yanzhe Li, Jie Li, Shen Li, Nannan Liu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |