Design, synthesis, structural characterization, and antioxidant potential of novel triazole- and oxadiazole-based hydrazide-hydrazone derivatives: spectroscopic, DFT, and molecular docking studies
Mariam A Abdo, Safa A Badawy, Ahmed A Fadda, Mohamed R Elmorsy · 2025
Read Design, synthesis, structural characterization, and antioxidant potential of novel triazole- and oxadiazole-based hydrazide-hydrazone derivatives: spectroscopic, DFT, and molecular docking studies by Mariam A Abdo, Safa A Badawy, Ahmed A Fadda, Mohamed R Elmorsy (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12849251.txt.
Description
Abdo, Badawy, Fadda, and Elmorsy design and make in twenty twenty-five a family of new ring-containing compounds and test their antioxidant strength. Starting from a nitro-bearing building block, they built nine variants through multi-step joining and ring-closing chemistry. Spectra and elemental checks confirmed each structure.
Several variants matched or beat vitamin C at soaking up test radicals. Computer models of electron layout helped explain which shapes should work best. Docking simulations showed some variants grip a key antioxidant switch protein in cells in a favourable way. The authors read the pattern as structure guiding activity. They present the family as leads for antioxidant drugs that work through that switch.
Catalog record
| CREATOR | Mariam A Abdo, Safa A Badawy, Ahmed A Fadda, Mohamed R Elmorsy |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |