Alterations in gut microbiome and fecal metabolome in functional dyspepsia patients: insights into pathophysiological mechanisms
Honghua Zhou, Ronghua Lu, You Lv, Yanbing Ding · 2025
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Description
Honghua Zhou and colleagues studied gut microbes and fecal chemistry in functional dyspepsia. Their 2025 paper seeks mechanisms behind this common gut disorder. Microbe imbalance is a known factor in its development. Past work focused on mouth, stomach, and upper gut lining microbes. Stool microbes and metabolites in these patients were less charted.
Samples came from thirty patients and nineteen healthy controls. Sequencing profiled gut bacteria while metabolomics profiled fecal chemicals. Patient samples showed greater microbe richness at similar diversity. Certain helpful genera fell, while others rose in patients. Correlation analysis linked shifted microbes to shifted metabolites. The paired data open new views on how dyspepsia arises. Diet or microbe therapies may follow from these patterns.
Catalog record
| CREATOR | Honghua Zhou, Ronghua Lu, You Lv, Yanbing Ding |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |