Tumor Microenvironment in Cancer Biology: A Comprehensive Review of Stromal, Immune, and Vascular Components Driving Malignancy
Sushma T A, Sudarshan Gupta, Priyanka Kiyawat, Yashodha Darshan, Kumar Sambhav, Saiyad Shabbirali Shamshadali · 2025
Read Tumor Microenvironment in Cancer Biology: A Comprehensive Review of Stromal, Immune, and Vascular Components Driving Malignancy by Sushma T A, Sudarshan Gupta, Priyanka Kiyawat, Yashodha Darshan, Kumar Sambhav, Saiyad Shabbirali Shamshadali (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12848954.txt.
Description
Sushma T A and five colleagues review the neighborhood that surrounds a tumor and shapes its fate, in a 2025 article. This microenvironment holds the matrix scaffold, stromal cells, immune cells, and blood vessels around cancer cells. Research long focused on the cancer cells alone, leaving the neighborhood understudied.
The review synthesizes recent work on each component. Cancer-linked fibroblasts remodel the matrix and damp the immune response, helping tumors grow. Abnormal vessels starve drug delivery and breed resistance. New tools, from single-cell sequencing to AI-assisted imaging, sharpen the picture of this crowded terrain. Therapies aimed at the neighborhood, including vessel-normalizing drugs, checkpoint inhibitors, and stroma-directed agents, show promise. Yet the terrain varies between patients and adapts under attack. The authors see neighborhood targeting as a major shift toward personalized cancer care.
Catalog record
| CREATOR | Sushma T A, Sudarshan Gupta, Priyanka Kiyawat, Yashodha Darshan, Kumar Sambhav, Saiyad Shabbirali Shamshadali |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |