Volatile and non-volatile pathogen cues shape host extracellular vesicles production in pre-infection response
Klaudia Kołodziejska, Agata Szczepańska, Satya Vadlamani, Ramakrishnan Ponath Sukumaran, Mariusz Radkiewicz, Henrik Bringmann, Nathalie Pujol, Wojciech Pokrzywa, Michał Turek · 2025
Read Volatile and non-volatile pathogen cues shape host extracellular vesicles production in pre-infection response by Klaudia Kołodziejska, Agata Szczepańska, Satya Vadlamani, Ramakrishnan Ponath Sukumaran, Mariusz Radkiewicz, Henrik Bringmann, Nathalie Pujol, Wojciech Pokrzywa, Michał Turek (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12847967.txt.
Description
Klaudia Kołodziejska and eight co-authors published a 2025 study on how worms release tiny vesicles when they sense danger from pathogens, before any infection. Animals meet pathogen chemicals in nature long before microbes invade. Extracellular vesicles carry signals that tune immunity and stress responses, but anticipatory control of them was unknown.
Working with the roundworm Caenorhabditis elegans, the team split pathogen cues into airborne and dissolved kinds. Dissolved cues, including one small peptide, switched on vesicle release through immune pathways. Airborne cues triggered release without immunity. Both routes needed the same three sensory neurons and fed into one neural circuit. Certain receptor proteins handled the dissolved cues, one acting from the gut. Offspring of exposed worms survived later infection better.
Catalog record
| CREATOR | Klaudia Kołodziejska, Agata Szczepańska, Satya Vadlamani, Ramakrishnan Ponath Sukumaran, Mariusz Radkiewicz, Henrik Bringmann, Nathalie Pujol, Wojciech Pokrzywa, Michał Turek |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 111 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |