Rhomboid protease GlpG regulates type 1 pili quality control and virulence in pathogenic E. coli
Jimmy Lu, Elena Arutyunova, Bridgette Hartley, Jonas Wong, Hyunjae Chung, Lanny Buchan, Heather Armstrong, Sadhna Phanse, Howard S Young, Eytan Wine, Mohan Babu, Justin Chun, Wael Elhenawy, Olivier Julien, M Joanne Lemieux · 2025
Read Rhomboid protease GlpG regulates type 1 pili quality control and virulence in pathogenic E. coli by Jimmy Lu, Elena Arutyunova, Bridgette Hartley, Jonas Wong, Hyunjae Chung, Lanny Buchan, Heather Armstrong, Sadhna Phanse, Howard S Young, Eytan Wine, Mohan Babu, Justin Chun, Wael Elhenawy, Olivier Julien, M Joanne Lemieux (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12847965.txt.
Description
Jimmy Lu and a large team wrote a 2025 study on a membrane-cutting enzyme that pathogenic Escherichia coli needs to build its attachment hairs. Type 1 pili are hair-like fibers the bacteria use to colonize host cells and form biofilms. The enzyme GlpG, a rhomboid protease, was known to matter for colonization, but not why.
Without GlpG's cutting activity, the bacteria fail to assemble proper pili. Biofilm production drops in turn, weakening persistence. Blocking the enzyme chemically also hampered biofilm formation, which flags GlpG as a drug target. The work casts GlpG as a quality control inspector for pilus parts. That role breaks the old paradigm that rhomboid proteases only cut substrates embedded in membranes. With antibiotic resistance rising, such fresh targets are valuable.
Catalog record
| CREATOR | Jimmy Lu, Elena Arutyunova, Bridgette Hartley, Jonas Wong, Hyunjae Chung, Lanny Buchan, Heather Armstrong, Sadhna Phanse, Howard S Young, Eytan Wine, Mohan Babu, Justin Chun, Wael Elhenawy, Olivier Julien, M Joanne Lemieux |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 77 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |