miR-139-5p suppresses hepatocellular carcinoma progression by targeting SMOX to inhibit AKT-mTOR pathway and epithelial-mesenchymal transition
Wenjun Pei, Kai Li, Yaping Bai, Li Ren, Anqi Mo, Jianping Mei, Hao Ding, Ruiyang Wang, Qianqian Zhao, Hui Wang · 2025
Read miR-139-5p suppresses hepatocellular carcinoma progression by targeting SMOX to inhibit AKT-mTOR pathway and epithelial-mesenchymal transition by Wenjun Pei, Kai Li, Yaping Bai, Li Ren, Anqi Mo, Jianping Mei, Hao Ding, Ruiyang Wang, Qianqian Zhao, Hui Wang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12847953.txt.
Description
Wenjun Pei and co-authors showed in 2025 how a tiny RNA strand slows liver cancer by blocking a helper enzyme. Cancer tissues and cell lines held far less of the strand than healthy ones, and low levels went with worse outcomes for patients. The team traced the strand's target and the paths it controls.
The strand latches onto the enzyme SMOX, which runs high in tumors and feeds two growth programs in cancer cells. Raising the strand cut cell growth, movement, and invasion in lab tests. Adding the enzyme back undid that brake, proving the link. The authors name both the strand and the enzyme as possible drug targets. Their work maps a chain that future treatments could aim at.
Catalog record
| CREATOR | Wenjun Pei, Kai Li, Yaping Bai, Li Ren, Anqi Mo, Jianping Mei, Hao Ding, Ruiyang Wang, Qianqian Zhao, Hui Wang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |