GBP2 condensates promote ferroptosis to sensitize anti-PD-L1 immunotherapy in melanoma
Xin Liu, Shilin Fang, Xianghai Ren, Yuntian Hong, Jianchun Guo, Xiaoping Liu, Liping Gao, Haihang Nie, Yumei Ning, Meng Zhang, Fei Xu, Lan Liu, Jun Fang, Yu Pang, Qiu Zhao, Fan Wang, Haizhou Wang · 2025
Read GBP2 condensates promote ferroptosis to sensitize anti-PD-L1 immunotherapy in melanoma by Xin Liu, Shilin Fang, Xianghai Ren, Yuntian Hong, Jianchun Guo, Xiaoping Liu, Liping Gao, Haihang Nie, Yumei Ning, Meng Zhang, Fei Xu, Lan Liu, Jun Fang, Yu Pang, Qiu Zhao, Fan Wang, Haizhou Wang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12847934.txt.
Description
Xin Liu and a large team find that condensates of a protein called GBP2 promote ferroptosis, an iron-driven form of cell death, and thereby sensitize melanoma to anti-PD-L1 immunotherapy. Immune checkpoint blockade often fails because tumors escape T cell killing by disrupting the interferon-gamma signal. Their 2025 study names GBP2, a protein induced by that signal, as a general amplifier of T cell cytotoxicity. It strengthens a key activation switch and suppresses a shield gene, priming tumor cells for ferroptotic death.
When the signal arrives, GBP2 clumps into droplets called condensates that trap a brake protein and keep the activation switch on. Break the condensates and ferroptosis fails, tumors grow fast, and T cell control fades. Dying cells release a signal protein that draws more T cells into the tumor. Boosting this pathway may make checkpoint therapy bite, the team holds.
Catalog record
| CREATOR | Xin Liu, Shilin Fang, Xianghai Ren, Yuntian Hong, Jianchun Guo, Xiaoping Liu, Liping Gao, Haihang Nie, Yumei Ning, Meng Zhang, Fei Xu, Lan Liu, Jun Fang, Yu Pang, Qiu Zhao, Fan Wang, Haizhou Wang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 82 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |