Heme drives cardiac endothelial senescence in sepsis via STING activation
Tingting Li, Peilin Zhu, Jialing Wang, Tao Zhang, Joseph Adams, Fei Tu, Chloe Garbe, Xiaojin Zhang, Li Liu, Krishna Singh, David L. Williams, Chuanfu Li, Xiaohui Wang · 2025
Read Heme drives cardiac endothelial senescence in sepsis via STING activation by Tingting Li, Peilin Zhu, Jialing Wang, Tao Zhang, Joseph Adams, Fei Tu, Chloe Garbe, Xiaojin Zhang, Li Liu, Krishna Singh, David L. Williams, Chuanfu Li, Xiaohui Wang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12847929.txt.
Description
Tingting Li and co-authors present lab work from 2025 on why the heart weakens in sepsis, a severe response to infection. The team found that cells lining heart blood vessels age fast in sepsis, and that this aging is a core part of the heart harm. Levels of heme, a part of blood that is freed when red cells break down, rose with the aging.
Tests showed that heme switches on a cell alarm protein called STING and makes the aging worse. Blocking that alarm helped the heart cells. So did raising hemopexin, a protein that clears heme from the blood. In sick mice, both steps cut the aging and helped the heart work better. The authors point to clearing heme as a possible new way to treat sepsis heart harm.
Catalog record
| CREATOR | Tingting Li, Peilin Zhu, Jialing Wang, Tao Zhang, Joseph Adams, Fei Tu, Chloe Garbe, Xiaojin Zhang, Li Liu, Krishna Singh, David L. Williams, Chuanfu Li, Xiaohui Wang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |