Connectivity of the adult human brain with sequential neurogenesis of circuits and transcriptomics signatures
Ibai Diez, Fernando García-Moreno, Nayara Carral-Sainz, Sebastiano Stramaglia, Alicia Nieto-Reyes, Mauro D’Amato, Jesús M Cortes, Paolo Bonifazi · 2025
Read Connectivity of the adult human brain with sequential neurogenesis of circuits and transcriptomics signatures by Ibai Diez, Fernando García-Moreno, Nayara Carral-Sainz, Sebastiano Stramaglia, Alicia Nieto-Reyes, Mauro D’Amato, Jesús M Cortes, Paolo Bonifazi (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12847928.txt.
Description
Ibai Diez and seven colleagues test whether the brain's wiring honors its embryonic construction order, in a study published in two thousand twenty-five. Their hypothesis: circuits born early in development become the connectome's strongest hubs. The brain's architecture would then carry a fossil record of its own assembly.
Brain regions were segmented by embryogenic age. Early-born nodes indeed showed greater structural centrality. Functional connectivity showed the opposite trend. Age gaps between regions predicted whether links existed and how strong they were. Gene expression data tied age and centrality to development and synapse genes. Developmental timing thus leaves measurable fingerprints on adult networks, with implications for why some hubs fail first in disease.
Catalog record
| CREATOR | Ibai Diez, Fernando García-Moreno, Nayara Carral-Sainz, Sebastiano Stramaglia, Alicia Nieto-Reyes, Mauro D’Amato, Jesús M Cortes, Paolo Bonifazi |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 88 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |