The Ku80-p53-SIRT1 axis in DNA damage response contributes to sporadic and familial ALS and FTD
Yong-Woo Jun, Soojin Lee, Sandra Almeida, Kristine K Freude, Justin K Ichida, Fen-Biao Gao · 2025
Read The Ku80-p53-SIRT1 axis in DNA damage response contributes to sporadic and familial ALS and FTD by Yong-Woo Jun, Soojin Lee, Sandra Almeida, Kristine K Freude, Justin K Ichida, Fen-Biao Gao (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12847843.txt.
Description
Yong-Woo Jun and co-authors trace in a 2025 study a DNA damage loop that drives nerve death in ALS and related dementia. Most cases share TDP-43 clumps, but other shared drivers stay murky. Lab grown neurons from patients offer a window on those shared paths.
Patient neurons showed low SIRT1 and high modified p53, alongside raised DNA damage. Adding SIRT1 back rescued the neurons and cut the modified p53 signal. Damage also lifted p53 marking and levels of the repair protein Ku80. Silencing p53 or Ku80 rescued neurons and restored SIRT1 in turn. Fruit fly eyes confirmed the loop's power in a living model as well.
Catalog record
| CREATOR | Yong-Woo Jun, Soojin Lee, Sandra Almeida, Kristine K Freude, Justin K Ichida, Fen-Biao Gao |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |