Morphological versus spherical cellular geometry models: impact on dose-response of CA20948 cells to 177Lu- and 161Tb-labeled DOTA-TATE and DOTA-LM3
Kaat Spoormans, Melissa Crabbé, Lara Struelens, Michel Koole · 2025
Read Morphological versus spherical cellular geometry models: impact on dose-response of CA20948 cells to 177Lu- and 161Tb-labeled DOTA-TATE and DOTA-LM3 by Kaat Spoormans, Melissa Crabbé, Lara Struelens, Michel Koole (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12847496.txt.
Description
Kaat Spoormans, Melissa Crabbé, Lara Struelens, and Michel Koole asked if cell shape warps dose math in a cancer therapy. Their study, from twenty twenty-five, deals with targeted radionuclide therapy. In this care, tagged drugs carry radiation to tumor cells. Flat cells stuck to a dish are not balls, yet plain models treat them as spheres. That gap can skew dose estimates.
The team built true shape cell models from microscope images of a rat tumor line. They then read dose for two radiation tags and two carrier drugs, in both shape models. Dose response curves were set for each pair. Readers who plan cell tests learn how much truth the ball model costs.
Catalog record
| CREATOR | Kaat Spoormans, Melissa Crabbé, Lara Struelens, Michel Koole |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 19 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |