Efficient Expression of Lactone Hydrolase Cr2zen for Scalable Zearalenone Degradation in Pichia pastoris
Mukhtar Ahmad, Hui Wang, Xiaomeng Liu, Shounan Wang, Tie Yin, Kun Deng, Caixia Lu, Xiaolin Zhang, Wei Jiang · 2025
Read Efficient Expression of Lactone Hydrolase Cr2zen for Scalable Zearalenone Degradation in Pichia pastoris by Mukhtar Ahmad, Hui Wang, Xiaomeng Liu, Shounan Wang, Tie Yin, Kun Deng, Caixia Lu, Xiaolin Zhang, Wei Jiang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12846278.txt.
Description
Nine researchers engineer a yeast system that breaks down a stubborn feed toxin, in a 2025 paper. The toxin, zearalenone, comes from Fusarium molds and mimics estrogen in animals and people. It survives heat and resists standard detox methods, which can spoil food value or leave residues.
The team took an enzyme from a fungus that naturally splits the toxin's ring. Grown plainly in the yeast Pichia pastoris, the enzyme worked weakly. Screening signal tags and rewriting the gene's code produced a variant that cleared over eighty percent of the toxin in tests under mild conditions. Large fermenter runs reached dense cultures with strong enzyme output. The authors say pairing protein tweaks with process tweaks gives a scalable route to safer feed. Wider use would still need checks in real feed settings.
Catalog record
| CREATOR | Mukhtar Ahmad, Hui Wang, Xiaomeng Liu, Shounan Wang, Tie Yin, Kun Deng, Caixia Lu, Xiaolin Zhang, Wei Jiang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |