Characterization of a Novel Family of Contilisant + Belinostat Multitarget Small Molecules in Glioblastoma
Aizpea Artetxe-Zurutuza, Nerea Iturrioz-Rodriguez, Joseba Elizazu, Raul Garcia-Garcia de Garayo, Irati de Goñi, Jhonatan Vergara, Mireia Toledano-Pinedo, Alicia Porro-Pérez, Mikel Azkargorta, Felix Elortza, Jose Luis Marco-Contelles, Nicolás Sampron, Ander Matheu · 2025
Read Characterization of a Novel Family of Contilisant + Belinostat Multitarget Small Molecules in Glioblastoma by Aizpea Artetxe-Zurutuza, Nerea Iturrioz-Rodriguez, Joseba Elizazu, Raul Garcia-Garcia de Garayo, Irati de Goñi, Jhonatan Vergara, Mireia Toledano-Pinedo, Alicia Porro-Pérez, Mikel Azkargorta, Felix Elortza, Jose Luis Marco-Contelles, Nicolás Sampron, Ander Matheu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12845422.txt.
Description
Aizpea Artetxe-Zurutuza and co-authors create a family of multi-target drugs against glioblastoma in a 2025 paper. This brain tumor is the most common and deadly of its kind in adults, and its mix of cell types helps it resist treatment. Drugs that hit several targets at once may do better than single-target ones.
The team merged features of two known compounds into nine new molecules. The designs aim at several enzymes and receptors tied to tumor growth and brain signaling. Most killed glioma cells in dishes. Three leads stood out, harmed tumor stem cells, and were predicted to reach the brain. One lead slowed tumors in animals, alone and with a standard drug, and disrupted cell cycle pathways in patient-derived cells.
Catalog record
| CREATOR | Aizpea Artetxe-Zurutuza, Nerea Iturrioz-Rodriguez, Joseba Elizazu, Raul Garcia-Garcia de Garayo, Irati de Goñi, Jhonatan Vergara, Mireia Toledano-Pinedo, Alicia Porro-Pérez, Mikel Azkargorta, Felix Elortza, Jose Luis Marco-Contelles, Nicolás Sampron, Ander Matheu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |