Causal Relationships Between the Oral Microbiome and Autoimmune Diseases: A Mendelian Randomization Study
Xinyu Wu, Xinye Zhang, Yuee Liang, Xuan Chen, Yuang Guo, Wanghong Zhao · 2025
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Description
Xinyu Wu and five co-authors ask whether mouth bacteria help cause autoimmune disease, or merely tag along. Links between the oral microbiome and diseases like lupus have been reported, but cause is hard to prove from such data. Their 2025 study uses Mendelian randomization, a method that uses gene variants as natural experiments. It tests six diseases, from rheumatoid arthritis to multiple sclerosis, against features of bacteria on the tongue and in saliva.
Built-in checks probe whether the results hold up and whether the arrow might run the other way, from disease to bacteria. Gene-based tests cannot be muddied by habits the way surveys can. The authors aim to sort which mouth microbes deserve lab follow-up as possible causes. The design covers hundreds of bacterial features.
Catalog record
| CREATOR | Xinyu Wu, Xinye Zhang, Yuee Liang, Xuan Chen, Yuang Guo, Wanghong Zhao |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |