Development and Pilot in Vivo Testing of a Protocol for PLGA–Vancomycin Coatings on PTFE Used as Silicone-Implant Analogs
Alina-Alexandra Negrilă, Oliviu Nica, Maria Viorica Ciocîlteu, Andrei Bită, Claudiu Nicolicescu, Alexandru-Bogdan Popescu, Marius-Eugen Ciurea · 2025
Read Development and Pilot in Vivo Testing of a Protocol for PLGA–Vancomycin Coatings on PTFE Used as Silicone-Implant Analogs by Alina-Alexandra Negrilă, Oliviu Nica, Maria Viorica Ciocîlteu, Andrei Bită, Claudiu Nicolicescu, Alexandru-Bogdan Popescu, Marius-Eugen Ciurea (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12843351.txt.
Description
Alina-Alexandra Negrilă and co-authors built antibiotic-loaded coatings for implant-like discs and tested them in rats, in a 2025 pilot study. Breast implants can draw infection and hostile tissue reactions, and drug-releasing coats might prevent both. The team loaded the antibiotic vancomycin into biodegradable PLGA microparticles and spread them on PTFE discs, stand-ins for smooth silicone implants.
Four rats each carried a plain-coated disc on one side and a drug-coated disc on the other, for four weeks. The team tracked healing and general condition, then examined the sites. The study's twin aims were practical: prove the coating workflow works, and set a gentle small-animal protocol for early testing. Results feed the design of safer implant surfaces.
Catalog record
| CREATOR | Alina-Alexandra Negrilă, Oliviu Nica, Maria Viorica Ciocîlteu, Andrei Bită, Claudiu Nicolicescu, Alexandru-Bogdan Popescu, Marius-Eugen Ciurea |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |