Vitamin D-Loaded Chitosan Nanostructures for Bone Regeneration: A Combined In Vitro and In Vivo Evaluation in an Osteoporotic Rat Model
Corina Giorgiana Muresan, Ioana Codruta Mirica, Alina Forray, Nausica Petrescu, Olga Soritau, Luciana-Mădălina Gherman, Simina Angela Lăcrimioara Iusan, Evelyn Vanea, Emilia Oprita, Ana Condor, Maria Aluas, Carmen Mihaela Mihu, Bianca Adina Boşca, Lavinia Patricia Mocan, Madalin Mihai Onofrei, Raluc · 2025
Read Vitamin D-Loaded Chitosan Nanostructures for Bone Regeneration: A Combined In Vitro and In Vivo Evaluation in an Osteoporotic Rat Model by Corina Giorgiana Muresan, Ioana Codruta Mirica, Alina Forray, Nausica Petrescu, Olga Soritau, Luciana-Mădălina Gherman, Simina Angela Lăcrimioara Iusan, Evelyn Vanea, Emilia Oprita, Ana Condor, Maria Aluas, Carmen Mihaela Mihu, Bianca Adina Boşca, Lavinia Patricia Mocan, Madalin Mihai Onofrei, Raluc (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12843211.txt.
Description
Corina Muresan and co-authors test a vitamin-loaded nano-scaffold for bone repair in weakened bone in a 2025 study. Osteoporosis makes jaw and bone rebuilding harder, and vitamin D aids bone growth but works poorly when given body-wide. A local scaffold could deliver the vitamin right at the defect.
The team built chitosan nanostructures carrying varied vitamin doses and tested them on human stem cells, then in rats whose ovaries were removed to mimic osteoporosis. One low dose stood out in dishes, with cell survival above control and more mineral deposits. In the rats, jaw defects treated with the loaded scaffold were checked at four and eight weeks against clot-only and sponge controls. The work supports local delivery for bone regeneration.
Catalog record
| CREATOR | Corina Giorgiana Muresan, Ioana Codruta Mirica, Alina Forray, Nausica Petrescu, Olga Soritau, Luciana-Mădălina Gherman, Simina Angela Lăcrimioara Iusan, Evelyn Vanea, Emilia Oprita, Ana Condor, Maria Aluas, Carmen Mihaela Mihu, Bianca Adina Boşca, Lavinia Patricia Mocan, Madalin Mihai Onofrei, Raluc |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |