Engineering Self-Assembled PEEK Scaffolds with Marine-Derived Exosomes and Bacteria-Targeting Aptamers for Enhanced Antibacterial Functions
Chen Zhang, Jinchao You, Runyi Lin, Yuansong Ye, Chuchu Cheng, Haopeng Wang, Dejing Li, Junxiang Wang, Shan Chen · 2025
Read Engineering Self-Assembled PEEK Scaffolds with Marine-Derived Exosomes and Bacteria-Targeting Aptamers for Enhanced Antibacterial Functions by Chen Zhang, Jinchao You, Runyi Lin, Yuansong Ye, Chuchu Cheng, Haopeng Wang, Dejing Li, Junxiang Wang, Shan Chen (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12842172.txt.
Description
Chen Zhang and co-authors build antibacterial bone scaffolds from a strong plastic, seaweed vesicles, and targeting strands. Bone implants often fail when bacteria infect the repair site. New implants that fight bacteria are in high demand.
The team printed porous PEEK scaffolds and coated them with a sticky dopamine layer. Onto that layer they placed exosomes drawn from fresh seaweed. The vesicles kill bacteria on their own in early tests. Short DNA strands that bind bacteria were added to aim the attack. The combined design seeks precise killing at the implant surface. It offers a path to safer bone repair in infected sites, where standard implants often struggle most.
Catalog record
| CREATOR | Chen Zhang, Jinchao You, Runyi Lin, Yuansong Ye, Chuchu Cheng, Haopeng Wang, Dejing Li, Junxiang Wang, Shan Chen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |