Transcriptomic Profiling of Cutibacterium acnes IA1—Infected Keratinocytes Reveal Hub Genes and CLR Pathway in Acne Pathogenesis
Jiawen Li, Fuxin Wang, Dangsheng Liu, Weichao Yang, Hao Sun, Mingfu Gao, Dawei Chen, Hui Xu · 2025
Read Transcriptomic Profiling of Cutibacterium acnes IA1—Infected Keratinocytes Reveal Hub Genes and CLR Pathway in Acne Pathogenesis by Jiawen Li, Fuxin Wang, Dangsheng Liu, Weichao Yang, Hao Sun, Mingfu Gao, Dawei Chen, Hui Xu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12839951.txt.
Description
Acne affects most teenagers, and one bacterial strain keeps showing up at the scene. Jiawen Li and co-authors infect skin keratinocyte cells with Cutibacterium acnes type IA1. After a day together, they read the cells' gene activity. Some 769 genes changed, split almost evenly between up and down. Network analysis found hub genes that anchor the response. A lectin receptor pathway stood out in the enrichment results.
Treated cells changed shape and poured out the inflammatory signal IL-6. The authors argue the bacterium drives acne through these hub genes, stirring gland inflammation and cell growth. They propose the hubs as targets for microbiome-based therapies, while noting the dish is not real skin.
Catalog record
| CREATOR | Jiawen Li, Fuxin Wang, Dangsheng Liu, Weichao Yang, Hao Sun, Mingfu Gao, Dawei Chen, Hui Xu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |