Exploring the Dynamic Interaction Between Pituitary Neuroendocrine Tumors (Pit-NETs) Cells and Their Angiogenic Microenvironment by Using the MIB1 Labeling Index, VEGF Expression and Digital Image Analysis
Mihaela Cozma, Anca Maria Cimpean, Mihail Parnov, Ana Silvia Corlan, Silvia Stratulat, Paula Fala, Eugen Melnic · 2025
Read Exploring the Dynamic Interaction Between Pituitary Neuroendocrine Tumors (Pit-NETs) Cells and Their Angiogenic Microenvironment by Using the MIB1 Labeling Index, VEGF Expression and Digital Image Analysis by Mihaela Cozma, Anca Maria Cimpean, Mihail Parnov, Ana Silvia Corlan, Silvia Stratulat, Paula Fala, Eugen Melnic (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12839843.txt.
Description
Mihaela Cozma and six co-authors study how pituitary tumors and their blood vessels grow in step, in a 2025 paper. Whether tumor cells and vessel lining cells divide together was in dispute. The team stained 109 tumors for vessel and growth markers and read them with a digital image tool. A growth signal gene and protein were also gauged.
Growth rates in tumor and vessel cells tracked each other closely. Two tumor types, one that makes prolactin and one that makes no hormone, showed high vessel growth. The growth signal's gene and protein levels tied to the tumor growth rate. Hormone type shaped the pattern in mixed ways. The authors back digital reads for risk sorting.
Catalog record
| CREATOR | Mihaela Cozma, Anca Maria Cimpean, Mihail Parnov, Ana Silvia Corlan, Silvia Stratulat, Paula Fala, Eugen Melnic |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |