ZIF-8 Hydrogel-Mediated Regulation of Macrophage Phenotype Accelerates Frostbite Wound Healing
Ge Lou, Yutong Li, Jinyu Zhao, Huihui Shao, Xianfu Wu, Heying Jin, Jianpeng Guo, Zhonggao Gao, Xing Jin, Mingji Jin, Shuangqing Wang · 2025
Read ZIF-8 Hydrogel-Mediated Regulation of Macrophage Phenotype Accelerates Frostbite Wound Healing by Ge Lou, Yutong Li, Jinyu Zhao, Huihui Shao, Xianfu Wu, Heying Jin, Jianpeng Guo, Zhonggao Gao, Xing Jin, Mingji Jin, Shuangqing Wang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12839219.txt.
Description
Ge Lou and co-authors published a research paper in 2025 on a hydrogel dressing that speeds healing of frostbite wounds. Frostbite leaves tissue starved, acidic, and inflamed, and current care cannot steer the many things going wrong. A plant compound that fights rust and swelling was promising but dissolves poorly and breaks down fast.
The team caged the compound in a zinc framework particle, then set the particles in a hyaluronic gel. The cage opened in acid, freeing most of the drug within a day and a half. In dishes it calmed inflammatory signals and coaxed immune cells toward healing mode. Mouse frostbite wounds closed far faster under the gel.
Catalog record
| CREATOR | Ge Lou, Yutong Li, Jinyu Zhao, Huihui Shao, Xianfu Wu, Heying Jin, Jianpeng Guo, Zhonggao Gao, Xing Jin, Mingji Jin, Shuangqing Wang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |