The Physiological Roles and Pathological Implications of Urea Transporters in the Cardiovascular System
Guangying Shao, Zhiwei Qiu, Min Li, Baoxue Yang, Xue Yu, Fusui Ji · 2025
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Description
Guangying Shao and co-authors wrote a 2025 review of urea transporters, proteins that move urea across cell membranes, and their roles in the heart and blood vessels. These proteins were long studied for their work in the kidneys, where they help concentrate urine. Newer work finds them in heart muscle and vessel lining cells as well.
In the heart system they help control cell water balance, a gas signal that relaxes vessels, the heart's electrical rhythm, and responses to stress. Faulty transport is now linked to high blood pressure, heart thickening and failure, rhythm faults, and vessel disease. The review weighs the promise and the hurdles of targeting these proteins with drugs.
Catalog record
| CREATOR | Guangying Shao, Zhiwei Qiu, Min Li, Baoxue Yang, Xue Yu, Fusui Ji |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |