Evaluation of Octenidine Dihydrochloride-Induced Cytotoxicity, Apoptosis, and Inflammatory Responses in Human Ocular Epithelial and Retinal Cells
Ihsan Hakki Ciftci, Asuman Deveci Ozkan, Gulay Erman, Imdat Kilbas, Ozlem Aydemir · 2025
Read Evaluation of Octenidine Dihydrochloride-Induced Cytotoxicity, Apoptosis, and Inflammatory Responses in Human Ocular Epithelial and Retinal Cells by Ihsan Hakki Ciftci, Asuman Deveci Ozkan, Gulay Erman, Imdat Kilbas, Ozlem Aydemir (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12838996.txt.
Description
Ihsan Hakki Ciftci and co-authors test how a germ killing compound, octenidine dihydrochloride, affects human eye cells in the lab. The compound kills a wide range of germs and stays stable, so eye uses are of interest. Data on its effects on eye tissue were thin before this 2025 study.
Two cell lines were used: one from the eye surface and one from the retina layer. Cell survival fell as dose rose, with the retina cells hit harder. A marker of cell suicide rose at the tested doses, which points to that death path. The compound also damped release of several inflammation signals. Gene tests tracked death, DNA damage, and inflammation genes.
Catalog record
| CREATOR | Ihsan Hakki Ciftci, Asuman Deveci Ozkan, Gulay Erman, Imdat Kilbas, Ozlem Aydemir |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |