Gut Microbial Composition and Short-Chain Fatty Acid Metabolism in Cognitively Unimpaired Adults Stratified by Amyloid-β Status
D. M. Sithara Dissanayaka, Thilini N. Jayasinghe, Hamid R. Sohrabi, S. R. Rainey-Smith, Kevin Taddei, Colin L. Masters, Ralph N. Martins, W. M. A. D. Binosha Fernando · 2025
Read Gut Microbial Composition and Short-Chain Fatty Acid Metabolism in Cognitively Unimpaired Adults Stratified by Amyloid-β Status by D. M. Sithara Dissanayaka, Thilini N. Jayasinghe, Hamid R. Sohrabi, S. R. Rainey-Smith, Kevin Taddei, Colin L. Masters, Ralph N. Martins, W. M. A. D. Binosha Fernando (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12838975.txt.
Description
Sithara Dissanayaka and co-authors published a 2025 study on gut microbes and brain health in older adults who still think clearly. Certain acids made by gut microbes when they ferment fiber affect body metabolism and brain inflammation. Both are tied to Alzheimer's disease. The team asked whether these acids and microbes link to amyloid, a protein that builds up in the brain early in that disease.
They studied eighty-seven adults with normal thinking. Stool samples were tested for the acids, and microbe species were profiled from their DNA. One acid, acetate, was the most common and showed the strongest microbe links. Higher acetate went with more of two helpful species. In people with more brain amyloid, the microbe-acid links looked stronger. The work hints that gut chemistry shifts may begin before memory problems do.
Catalog record
| CREATOR | D. M. Sithara Dissanayaka, Thilini N. Jayasinghe, Hamid R. Sohrabi, S. R. Rainey-Smith, Kevin Taddei, Colin L. Masters, Ralph N. Martins, W. M. A. D. Binosha Fernando |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |