Chronic Alcohol Use and Accelerated Brain Aging: Shared Mechanisms with Alzheimer’s Disease Pathophysiology
Nishtha Singh, Shouvik Kumar Nandy, Aditi Sharma, Vansh, Arif Jamal Siddiqui, Lalit Sharma · 2025
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Description
Nishtha Singh and five colleagues review how chronic heavy drinking ages the brain through paths much like those of Alzheimer's disease. Heavy alcohol use harms the hippocampus, prefrontal cortex, amygdala, cerebellum, and hypothalamus. These are the regions that carry memory and judgment.
The shared paths include oxidative stress, microglial inflammation, tau protein hyperphosphorylation, changed amyloid turnover, and disrupted cholinergic signaling. That last one drives memory loss. Claims that light drinking helps stay murky, since studies define drinking in mixed ways and confounders abound. The authors conclude the link depends on dose. Heavy use raises the risk of Alzheimer's-type decline, so cutting harmful drinking is a practical lever for lowering long-term dementia risk.
Catalog record
| CREATOR | Nishtha Singh, Shouvik Kumar Nandy, Aditi Sharma, Vansh, Arif Jamal Siddiqui, Lalit Sharma |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |