Phosvitin-Derived Peptide Pt5-1c Is a Pro-Angiogenic Agent Capable of Enhancing Wound Healing
Cuiling Xuan, Mei Li, Peng Zhang, Yunchao Wang, Hongyan Li, Zhiqin Gao, Shicui Zhang, Fei Wu · 2025
Read Phosvitin-Derived Peptide Pt5-1c Is a Pro-Angiogenic Agent Capable of Enhancing Wound Healing by Cuiling Xuan, Mei Li, Peng Zhang, Yunchao Wang, Hongyan Li, Zhiqin Gao, Shicui Zhang, Fei Wu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12838811.txt.
Description
Cuiling Xuan and colleagues turn a fish egg peptide into a blood-vessel recruiter for stubborn wounds, in this study from twenty twenty-five. The peptide, Pt5-1c, comes from phosvitin and belongs to the antimicrobial peptide family, several of which moonlight in healing. In mice with full-thickness wounds and in zebrafish with defective vessels, it measurably sped vessel growth and closure.
In cell work it made endothelial cells move, stick, survive, and sprout tubes, the full angiogenesis repertoire. It raised the classic vessel growth factors, VEGF, PDGF, FGF, and EGF, and fired two growth pathways plus the oxygen-sensing HIF axis that commands VEGF. The authors nominate the peptide as a candidate for regenerative therapy where wounds stall for want of blood supply.
Catalog record
| CREATOR | Cuiling Xuan, Mei Li, Peng Zhang, Yunchao Wang, Hongyan Li, Zhiqin Gao, Shicui Zhang, Fei Wu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |