Centrally Acting Skeletal Muscle Relaxants Sharing Molecular Targets with Drugs for Neuropathic Pain Management
Judit Mária Kirchlechner-Farkas, David Arpad Karadi, Imre Boldizsár, Nariman Essmat, Anna Rita Galambos, Zoltán Patrik Lincmajer, Sarah Kadhim Abbood, Kornél Király, Éva Szökő, Tamás Tábi, Mahmoud Al-Khrasani · 2025
Read Centrally Acting Skeletal Muscle Relaxants Sharing Molecular Targets with Drugs for Neuropathic Pain Management by Judit Mária Kirchlechner-Farkas, David Arpad Karadi, Imre Boldizsár, Nariman Essmat, Anna Rita Galambos, Zoltán Patrik Lincmajer, Sarah Kadhim Abbood, Kornél Király, Éva Szökő, Tamás Tábi, Mahmoud Al-Khrasani (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12838608.txt.
Description
Judit Mária Kirchlechner-Farkas, David Arpad Karadi, Imre Boldizsár, and a wider team wrote this review paper, published in 2025. It argues that some muscle relaxants acting on the brain may double as treatments for neuropathic pain, nerve pain that current drugs relieve well in only about a third of patients.
The review focuses on tolperisone, a relaxant that blocks sodium channels in nerve cells and also tunes calcium channels. Those are the same targets as several proven nerve pain drugs. Early animal studies of tolperisone for nerve pain came out positive. Paired with pregabalin, it recently halted nerve pain in tests. The authors propose a deliberate strategy: combine sodium channel blockers with calcium channel blockers, or find single drugs that do both, to widen the options for a stubborn condition.
Catalog record
| CREATOR | Judit Mária Kirchlechner-Farkas, David Arpad Karadi, Imre Boldizsár, Nariman Essmat, Anna Rita Galambos, Zoltán Patrik Lincmajer, Sarah Kadhim Abbood, Kornél Király, Éva Szökő, Tamás Tábi, Mahmoud Al-Khrasani |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |