PCSK9 in Cancer: Biological Mechanisms and Implications for Therapeutic Resistance
Nuriza Ulul Azmi, Rezi Riadhi Syahdi, Meidi Utami Puteri, Arry Yanuar, Mitsuyasu Kato, Fadlina Chany Saputri · 2025
Read PCSK9 in Cancer: Biological Mechanisms and Implications for Therapeutic Resistance by Nuriza Ulul Azmi, Rezi Riadhi Syahdi, Meidi Utami Puteri, Arry Yanuar, Mitsuyasu Kato, Fadlina Chany Saputri (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12838582.txt.
Description
Azmi and co-authors review what a cholesterol-regulating protein is doing inside cancers, in a 2025 paper. PCSK9 is famous for removing LDL receptors and raising blood cholesterol. Newer evidence gives it darker talents in tumors: helping cells survive stress, hiding them from the immune system by stripping recognition tags, and reshuffling membrane receptors.
Those same tricks may blunt cancer treatments, fostering drug tolerance and resistance. The review gathers current knowledge on the protein's cancer biology and asks how each pathway could affect therapy response. The authors position PCSK9 as both a risk factor worth watching and a possible target.
Catalog record
| CREATOR | Nuriza Ulul Azmi, Rezi Riadhi Syahdi, Meidi Utami Puteri, Arry Yanuar, Mitsuyasu Kato, Fadlina Chany Saputri |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |