Tear fluid calcitonin gene-related peptide (CGRP) is elevated during spontaneous migraine attacks – results from a pilot study
Katharina Kamm, Annika Brandi-Dohrn, Andreas Straube, Stefanie Förderreuther, Ruth Ruscheweyh · 2025
Read Tear fluid calcitonin gene-related peptide (CGRP) is elevated during spontaneous migraine attacks – results from a pilot study by Katharina Kamm, Annika Brandi-Dohrn, Andreas Straube, Stefanie Förderreuther, Ruth Ruscheweyh (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12838498.txt.
Description
Katharina Kamm and co-authors published a pilot study in 2025 on migraine. A small protein in the body plays a key role in migraine attacks. Its level in blood is hard to read, since blood dilutes it and it breaks down fast. The team tested whether tears carry a clearer signal.
Fourteen women with migraine gave tear samples on two days. One day was pain-free; the other fell during a real attack. Tear levels of the protein were higher at peak pain than at rest or after the pain eased. The rise was largest when the sample came within three hours of the attack start. The authors say tear tests may one day serve as a marker for migraine.
Catalog record
| CREATOR | Katharina Kamm, Annika Brandi-Dohrn, Andreas Straube, Stefanie Förderreuther, Ruth Ruscheweyh |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 21 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |