A combined study of pharmacodynamics and pharmacokinetics of methamphetamine and its metabolite in male mice
Hongliang Su, Lingxiao Wang, Xiaoxiao Huang, Jinkai Wang, Yi Zhang, Yanhua Li, Yan Du, Xiaomeng Sun, Chao Zhang, Zhiwen Wei, Keming Yun · 2025
Read A combined study of pharmacodynamics and pharmacokinetics of methamphetamine and its metabolite in male mice by Hongliang Su, Lingxiao Wang, Xiaoxiao Huang, Jinkai Wang, Yi Zhang, Yanhua Li, Yan Du, Xiaomeng Sun, Chao Zhang, Zhiwen Wei, Keming Yun (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12838478.txt.
Description
Hongliang Su and co-authors mapped how methamphetamine moves through male mice and how long its effects last, in a 2025 study. The drug is a strong stimulant with high risk of dependence. Knowing when its brain effects peak helps teams plan studies of how it harms and hooks users.
The team tracked mouse movement and drug levels in blood and brain from five minutes to eight hours after a dose. Movement stayed high for the first hour and fell off by two hours. The drug peaked in blood at five minutes, while its breakdown product peaked an hour later; both peaked in the brain at half an hour. The authors name the first one to two hours as the best window for studying the drug's brain effects.
Catalog record
| CREATOR | Hongliang Su, Lingxiao Wang, Xiaoxiao Huang, Jinkai Wang, Yi Zhang, Yanhua Li, Yan Du, Xiaomeng Sun, Chao Zhang, Zhiwen Wei, Keming Yun |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |