A Multikinase Inhibitor AX-0085 Blocks FGFR1 Activation to Overcomes Osimertinib Resistance in Non-Small Cell Lung Cancer
Byung-Ho Rhie, Janardhan Keshav Karapurkar, Hyun-Yi Kim, Sang Hyeon Woo, D. A. Ayush Gowda, Dong Ha Kim, Myeong Jun Choi, Young Jun Park, Viswanathaiah Matam, Yoonki Hong, Seok-Ho Hong, Suresh Ramakrishna, Kye-Seong Kim · 2025
Read A Multikinase Inhibitor AX-0085 Blocks FGFR1 Activation to Overcomes Osimertinib Resistance in Non-Small Cell Lung Cancer by Byung-Ho Rhie, Janardhan Keshav Karapurkar, Hyun-Yi Kim, Sang Hyeon Woo, D. A. Ayush Gowda, Dong Ha Kim, Myeong Jun Choi, Young Jun Park, Viswanathaiah Matam, Yoonki Hong, Seok-Ho Hong, Suresh Ramakrishna, Kye-Seong Kim (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12838157.txt.
Description
Byung-Ho Rhie and co-authors test a new drug against lung cancers that stop responding to a standard targeted pill, in a 2025 lab study. The pill, osimertinib, works at first on cancers with a changed growth gene, but tumors often find a way around it. Two side paths, run by proteins called AXL and FGFR1, help many tumors escape. The team grew resistant cancer cells in the lab and treated them with the new drug, AX-0085.
The drug blocked both side paths at once. Treated cells grew more slowly, formed fewer colonies, and moved less than untreated ones. Gene scans showed the escape paths quieted after dosing. The cells also grew sensitive to the old pill again. The authors back wider tests of the drug for patients whose tumors resist the standard pill.
Catalog record
| CREATOR | Byung-Ho Rhie, Janardhan Keshav Karapurkar, Hyun-Yi Kim, Sang Hyeon Woo, D. A. Ayush Gowda, Dong Ha Kim, Myeong Jun Choi, Young Jun Park, Viswanathaiah Matam, Yoonki Hong, Seok-Ho Hong, Suresh Ramakrishna, Kye-Seong Kim |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |