Potential Impact of Microbial Dysbiosis and Tryptophan Metabolites in Advanced Stages of Colorectal Cancer
Anne Hulin, Aline Rifflet, Florence Castelli, Quentin Giai Gianetto, François Fenaille, Abdel Aissat, Mariette Matondo, Soraya Fellahi, Christophe Tournigand, Christophe Junot, Philippe Sansonetti, Ivo Gomperts-Boneca, Denis Mestivier, Iradj Sobhani · 2025
Read Potential Impact of Microbial Dysbiosis and Tryptophan Metabolites in Advanced Stages of Colorectal Cancer by Anne Hulin, Aline Rifflet, Florence Castelli, Quentin Giai Gianetto, François Fenaille, Abdel Aissat, Mariette Matondo, Soraya Fellahi, Christophe Tournigand, Christophe Junot, Philippe Sansonetti, Ivo Gomperts-Boneca, Denis Mestivier, Iradj Sobhani (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12838134.txt.
Description
Anne Hulin and co-authors probe gut microbes and body chemistry in late-stage colon cancer, in a 2025 study. They sampled blood, urine, and stool water from patients before a bowel exam. Healthy volunteers gave samples for comparison. The team measured small molecules in each sample and read the gut microbe mix from stool DNA.
Patients with the most advanced cancer showed clear shifts. Bile-related compounds fell in blood but rose in urine, and fat-related compounds dropped. Paths that break down an amino acid called tryptophan swung toward one branch and away from another. The shifts tracked with more harmful gut bacteria and fewer helpful ones. The authors suggest one tryptophan product may flag a failing immune response during treatment.
Catalog record
| CREATOR | Anne Hulin, Aline Rifflet, Florence Castelli, Quentin Giai Gianetto, François Fenaille, Abdel Aissat, Mariette Matondo, Soraya Fellahi, Christophe Tournigand, Christophe Junot, Philippe Sansonetti, Ivo Gomperts-Boneca, Denis Mestivier, Iradj Sobhani |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |