Antioxidant and Neuroprotective Capacity of Resveratrol-Loaded Polymeric Micelles in In Vitro and In Vivo Models with Generated Oxidative Stress
Maria Lazarova, Elina Tsvetanova, Almira Georgieva, Miroslava Stefanova, Krasimira Tasheva, Lyubomira Radeva, Magdalena Kondeva-Burdina, Krassimira Yoncheva · 2025
Read Antioxidant and Neuroprotective Capacity of Resveratrol-Loaded Polymeric Micelles in In Vitro and In Vivo Models with Generated Oxidative Stress by Maria Lazarova, Elina Tsvetanova, Almira Georgieva, Miroslava Stefanova, Krasimira Tasheva, Lyubomira Radeva, Magdalena Kondeva-Burdina, Krassimira Yoncheva (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12837955.txt.
Description
Maria Lazarova and co-authors package resveratrol, the red-wine polyphenol, into tiny polymer bubbles to make its antioxidant power usable. Pure resveratrol is a strong antioxidant on paper but absorbs badly in the body. Their 2025 study compares the free compound against the micelle-loaded form across bench antioxidant tests, a nerve toxicity model in brain tissue, and rats given a memory-damaging drug.
In the chemical tests the loaded form reduced iron more strongly. In the tissue model it preserved cell viability and glutathione, the cell's own antioxidant store, in a dose-linked way. In the rats, the micelle form best supported recognition memory, protected the hippocampus from fat oxidation damage, and kept glutathione up in the cortex, all ahead of the pure drug. The authors conclude that the packaging, not just the molecule, decides the benefit.
Catalog record
| CREATOR | Maria Lazarova, Elina Tsvetanova, Almira Georgieva, Miroslava Stefanova, Krasimira Tasheva, Lyubomira Radeva, Magdalena Kondeva-Burdina, Krassimira Yoncheva |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |