Multimodal Implementations to Reduce Neonatal Ventilator-Associated Pneumonia and Colistin Use: An Interrupted Time Series
Gunlawadee Maneenil, Anucha Thatrimontrichai, Praew Chareesri, Pattima Pakhathirathien, Manapat Praditaukrit, Supaporn Dissaneevate, Supika Kritsaneepaiboon, Anucha Apisarnthanarak · 2025
Read Multimodal Implementations to Reduce Neonatal Ventilator-Associated Pneumonia and Colistin Use: An Interrupted Time Series by Gunlawadee Maneenil, Anucha Thatrimontrichai, Praew Chareesri, Pattima Pakhathirathien, Manapat Praditaukrit, Supaporn Dissaneevate, Supika Kritsaneepaiboon, Anucha Apisarnthanarak (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12837886.txt.
Description
Babies on ventilators can develop lung infections that drive up antibiotic use, and one Thai intensive care unit spent a decade pushing both down. Gunlawadee Maneenil and seven co-authors report that effort in a 2025 study. The unit rolled out changes in three waves between 2014 and 2024.
The first wave brought stronger cleaning, moisture exchangers on breathing circuits, and gentler ventilation modes. The second added mouth care with the mother's own milk. The third changed the support given right after the breathing tube came out. Over 11 years, 2,470 of 5,414 babies were intubated. Infections ran at 4.55 per 1,000 ventilator days overall, and yearly rates fell below the 2014 level. Use of colistin, a last-resort antibiotic, eased during the first wave. The authors read the trend as slow, stacked gains.
Catalog record
| CREATOR | Gunlawadee Maneenil, Anucha Thatrimontrichai, Praew Chareesri, Pattima Pakhathirathien, Manapat Praditaukrit, Supaporn Dissaneevate, Supika Kritsaneepaiboon, Anucha Apisarnthanarak |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |