Pharmacologic Inhibition of S-Nitrosoglutathione Reductase Prevents Hyperoxic Alveolar and Airway Disease in Newborn Mice
Stephanie Adaikalam, Ramadan B. Sopi, Laura A. Smith, Anjum Jafri, Peter M. MacFarlane, Richard J. Martin, Benjamin Gaston, Thomas M. Raffay · 2025
Read Pharmacologic Inhibition of S-Nitrosoglutathione Reductase Prevents Hyperoxic Alveolar and Airway Disease in Newborn Mice by Stephanie Adaikalam, Ramadan B. Sopi, Laura A. Smith, Anjum Jafri, Peter M. MacFarlane, Richard J. Martin, Benjamin Gaston, Thomas M. Raffay (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12837470.txt.
Description
Stephanie Adaikalam and co-authors test, in a 2025 study, whether blocking a certain enzyme can protect the lungs of newborn mice exposed to high oxygen. Babies born early often need oxygen, which can leave lasting lung and airway harm. Blocking the enzyme had earlier eased airway twitchiness in such a mouse model.
Newborn mice breathed high oxygen for five days while getting the drug or plain saline. Three weeks later, treated mice showed less lung scarring of the air sacs and better airway support. Their airways also reacted less to a test spray. Gains grew with dose. The work supports early drug treatment as a way to limit lasting harm.
Catalog record
| CREATOR | Stephanie Adaikalam, Ramadan B. Sopi, Laura A. Smith, Anjum Jafri, Peter M. MacFarlane, Richard J. Martin, Benjamin Gaston, Thomas M. Raffay |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |