TELO2 mediates parabens-induced breast carcinogenesis: a comprehensive network analysis
Jing Ren, Xiaofen Li, Bin Dong, Zhulin Bu, Yuhui Wu, Yuting Li, Lin Yang, Huaixi Xing, Yuting Dai, Shuosheng Zhang, Xianglong Meng · 2025
Read TELO2 mediates parabens-induced breast carcinogenesis: a comprehensive network analysis by Jing Ren, Xiaofen Li, Bin Dong, Zhulin Bu, Yuhui Wu, Yuting Li, Lin Yang, Huaixi Xing, Yuting Dai, Shuosheng Zhang, Xianglong Meng (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12837177.txt.
Description
Jing Ren and co-authors used network analysis in 2025 to probe how parabens, common preservatives in cosmetics, may promote breast cancer. Parabens are linked to higher breast cancer risk, but the molecular route was unclear. The team combined several methods, from network toxicology to genetic causal analysis and molecular docking.
Thousands of possible paraben targets were narrowed to a set tied to breast cancer, with two major pathways standing out. Genetic analysis flagged one gene, TELO2, as a risk factor for both malignant and benign breast tumors. Its levels were higher in tumor tissue and separated cases from controls well. Docking showed parabens bind the TELO2 protein stably, and immune cells carried part of the link.
Catalog record
| CREATOR | Jing Ren, Xiaofen Li, Bin Dong, Zhulin Bu, Yuhui Wu, Yuting Li, Lin Yang, Huaixi Xing, Yuting Dai, Shuosheng Zhang, Xianglong Meng |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |