Engineering chitosan fibers with MSC-exosome cargo: a clinically translatable multifunctional dressing for regenerative therapy in infected wound management
Jing Gao, Rui Qiao, Chenyong Fu, Di Sun, Dan Jin, Qing Zhang, Zhe Li, Guanjing Lang · 2025
Read Engineering chitosan fibers with MSC-exosome cargo: a clinically translatable multifunctional dressing for regenerative therapy in infected wound management by Jing Gao, Rui Qiao, Chenyong Fu, Di Sun, Dan Jin, Qing Zhang, Zhe Li, Guanjing Lang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12837088.txt.
Description
Gao and co-authors weave shellfish-derived fibers into a wound dressing, then load it with healing parcels from stem cells. Chronic infected wounds stall because microbes colonize them and repair cells switch off. Their 2025 dressing blends two forms of chitosan fiber into a nonwoven fabric that locks in moisture, kills germs, and stops bleeding.
Stem cell parcels called exosomes are then stuck to the fibers by static charge. In bench tests the blend beat either fiber alone on strength, wetness retention, and germ killing against two common bacteria. Bleeding stopped faster with less blood lost. In rats with infected skin wounds, the loaded dressing healed fastest, with rich new blood vessel growth. The authors pitch it as a scalable, clinic-ready option.
Catalog record
| CREATOR | Jing Gao, Rui Qiao, Chenyong Fu, Di Sun, Dan Jin, Qing Zhang, Zhe Li, Guanjing Lang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |