Aldolase a coordinates macropinocytic nutrient scavenging and lysosomal degradation in lung cancer by interacting with V-ATPase
Daehoon Kim, Seokmin Jeong, Seunghyeong Lee, Jonghwa Jin, Jae Won Yun, Jaebon Lee, Jun-Kyu Byun, Yeon-Kyung Choi, Keun-Gyu Park · 2025
Read Aldolase a coordinates macropinocytic nutrient scavenging and lysosomal degradation in lung cancer by interacting with V-ATPase by Daehoon Kim, Seokmin Jeong, Seunghyeong Lee, Jonghwa Jin, Jae Won Yun, Jaebon Lee, Jun-Kyu Byun, Yeon-Kyung Choi, Keun-Gyu Park (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12837057.txt.
Description
Daehoon Kim and colleagues show how a lung cancer enzyme moonlights as a recycling manager. Cancers with KRAS mutations gulp down outside proteins for food when nutrients run low. The cell's lysosomes must digest that haul, and the sugar enzyme aldolase A turns out to coordinate the digestion.
High aldolase A levels tracked with poor survival in KRAS-mutant lung cancer. The enzyme does not change how much protein cells swallow. Instead it binds the lysosome's acid pump and sharpens the acid that breaks cargo down. Cutting that link starved the process. The side job makes the enzyme a fresh drug target.
Catalog record
| CREATOR | Daehoon Kim, Seokmin Jeong, Seunghyeong Lee, Jonghwa Jin, Jae Won Yun, Jaebon Lee, Jun-Kyu Byun, Yeon-Kyung Choi, Keun-Gyu Park |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |