Manganese-enriched nanoboron agent amplifies BNCT efficacy via pyroptosis-mediated immune activation and STING pathway synergy
Zhicheng Zhang, Xiaoyan Sun, Yaxin Qin, Yufan Yang, Qi Dai, Xiaoyan Bao, Minoru Suzuki, Sheng Wang, Zai Yang, Zhifeng Li, Min Han, Donghang Xu, Qichun Wei · 2025
Read Manganese-enriched nanoboron agent amplifies BNCT efficacy via pyroptosis-mediated immune activation and STING pathway synergy by Zhicheng Zhang, Xiaoyan Sun, Yaxin Qin, Yufan Yang, Qi Dai, Xiaoyan Bao, Minoru Suzuki, Sheng Wang, Zai Yang, Zhifeng Li, Min Han, Donghang Xu, Qichun Wei (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12837054.txt.
Description
Zhicheng Zhang and co-authors present a 2025 cancer study on boosting a targeted radiation method called BNCT. Boron neutron capture therapy kills tumor cells that have soaked up boron, sparing healthy tissue. Its power is capped by immune suppression after treatment and by peroxide buildup inside tumors.
The team built a nano-agent that pairs boron delivery with manganese dioxide, wrapped in a protein shell. The manganese drives a Fenton-like reaction that raises oxidative stress and wakes the STING immune pathway. Treated tumor cells die by pyroptosis, a fiery death that alerts the immune system. Killer T cell responses and interferon signaling rose as a result. The agent also shows on MRI scans, merging diagnosis with therapy. Tumors shrank even at low boron levels.
Catalog record
| CREATOR | Zhicheng Zhang, Xiaoyan Sun, Yaxin Qin, Yufan Yang, Qi Dai, Xiaoyan Bao, Minoru Suzuki, Sheng Wang, Zai Yang, Zhifeng Li, Min Han, Donghang Xu, Qichun Wei |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |