Host immunogenetics and EBV detection in cancer: the CTLA-4 rs231775 signal in a multi-cancer case–control cohort
Noor Kadhim Abed, Abolfazl Bayrami, Saber Zahri · 2025
Read Host immunogenetics and EBV detection in cancer: the CTLA-4 rs231775 signal in a multi-cancer case–control cohort by Noor Kadhim Abed, Abolfazl Bayrami, Saber Zahri (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12836939.txt.
Description
Some viruses linger and may help cancer grow, and immune genes could decide which viruses persist. Noor Kadhim Abed, Abolfazl Bayrami, and Saber Zahri study 90 cancer patients and 90 matched controls from southern Iraq. They test blood and tumor samples, where available, for DNA of Epstein-Barr virus, HPV, and hepatitis B virus, and genotype two immune genes, CTLA-4 and IL-4.
Viral DNA turned up in about two-thirds of patients and in no controls. Among patients, hepatitis B was most common, then Epstein-Barr, then HPV. One gene variant stood out: patients carrying the GA form of CTLA-4 rs231775 were more likely to test positive for Epstein-Barr virus, even after adjusting for age, sex, and cancer type. Two other variants showed no link. Because no control carried the virus, the authors stress the finding rests on contrasts among patients and needs testing in larger groups.
Catalog record
| CREATOR | Noor Kadhim Abed, Abolfazl Bayrami, Saber Zahri |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |