Study on the synthesis, physicochemical properties and transdermal absorption of scutellarein prodrugs
Ping Wang, Hong-jian Yu, Zhi-qi Yin, Chang-wei Zhou · 2025
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Description
Ping Wang and three co-authors wrote a 2025 study on redesigning a plant compound so skin can absorb it better. Scutellarein, a flavonoid, fights psoriasis in principle, but it dissolves poorly in fat and barely crosses skin. The team used a prodrug strategy: attach temporary chemical groups that the body later removes.
They synthesized 19 prodrugs in three chemical families. Three stood out for balancing fat solubility with workable water solubility. In skin tests, all three crossed far better than the parent compound and lingered longer in the skin. In mice with psoriasis-like lesions, the prodrugs visibly eased back lesions and cut epidermal thickening and cell growth markers. The study delivers candidate compounds for psoriasis creams. It shows prodrug design can rescue a promising but poorly absorbed molecule.
Catalog record
| CREATOR | Ping Wang, Hong-jian Yu, Zhi-qi Yin, Chang-wei Zhou |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |