AAD-2004 through clearing H2O2 reduces astrocyte proliferation and promotes neural regeneration after spinal cord injury
Xiaodan Mi, Keming Shan, Xiangming Ye, Ruidong Cheng · 2025
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Description
Four authors, led by Xiaodan Mi, test a 2025 drug called AAD-2004 in spinal cord injury, using cells and mice. The drug mops up hydrogen peroxide, a harsh chemical that builds up after harm. It had shown protective effects in nerve illness before. Here the team asked if it could help the cord heal.
In cell tests the drug cut cell death and lowered the harsh chemical. In mice it curbed the growth of support cells that form scar tissue. Treated mice moved better and showed more signs of nerve regrowth. The results point to clearing the chemical as one path to repair.
Catalog record
| CREATOR | Xiaodan Mi, Keming Shan, Xiangming Ye, Ruidong Cheng |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |