Quinic acid attenuates arsenic-induced hepatic injury and hyperglycemia in mice via GLUT2 upregulation and suppression of oxidative stress and inflammation
Seyedeh Diba Aghamirzadeh, Mohammad Javad Khodayar, Mehrnoush Matin, Annahita Rezaie, Mehrnoosh Moosavi · 2025
Read Quinic acid attenuates arsenic-induced hepatic injury and hyperglycemia in mice via GLUT2 upregulation and suppression of oxidative stress and inflammation by Seyedeh Diba Aghamirzadeh, Mohammad Javad Khodayar, Mehrnoush Matin, Annahita Rezaie, Mehrnoosh Moosavi (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12834986.txt.
Description
Seyedeh Diba Aghamirzadeh and co-authors tested, in a 2025 mouse study, whether quinic acid shields the liver and blood sugar from arsenic poisoning. Long arsenic exposure raises diabetes risk, and the plant compound is known for antioxidant and anti-inflammatory action. Mice were split into six groups, mixing arsenic dosing with three acid doses over 28 days.
Arsenic alone wrecked glucose tolerance, inflamed and injured the liver, and drained antioxidant defenses. Adding quinic acid softened every one of those harms and restored glycemic control, more so at higher doses. A liver glucose transporter, GLUT2, which arsenic had suppressed, climbed back dose by dose. Tissue slices told the same story. The authors frame the compound as a candidate protectant where arsenic contaminates water and food.
Catalog record
| CREATOR | Seyedeh Diba Aghamirzadeh, Mohammad Javad Khodayar, Mehrnoush Matin, Annahita Rezaie, Mehrnoosh Moosavi |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |