Targeting cell surface GRP78-CD44v interaction suppresses cell migration in triple-negative breast cancer cells
Chun-Chih Tseng, Pu Zhang, Mari B Ishak Gabra, Mei Kong, Amy S Lee · 2025
Read Targeting cell surface GRP78-CD44v interaction suppresses cell migration in triple-negative breast cancer cells by Chun-Chih Tseng, Pu Zhang, Mari B Ishak Gabra, Mei Kong, Amy S Lee (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12834970.txt.
Description
Chun-Chih Tseng and co-authors find in 2025 a surface pairing that helps an aggressive breast cancer move. Triple-negative breast cancer lacks the usual drug targets. A stress protein, GRP78, normally works inside cells but shows up on the surface of these cancer cells, where normal tissue rarely displays it.
Over 70 percent of the studied cancer cells carried the surface protein. It clustered at the cell's front edge together with a variant of CD44, a known migration aid. An antibody against the surface protein lowered the partner's levels, broke the cell's moving shape, and slowed migration. Tumors in mice showed the same pairing. The authors propose the pair as a drug target.
Catalog record
| CREATOR | Chun-Chih Tseng, Pu Zhang, Mari B Ishak Gabra, Mei Kong, Amy S Lee |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |