Sox11 overexpression restores embryonic pro-growth transcription in mature corticospinal tract neurons
Elizabeth Batsel, Zimei Wang, Elizabeth Otten, Syed Roshan, Rabia Mohammad, Paula Pascual, Darby O’Shea, Jose Rosas, Pantelis Tsoulfas, Murray G. Blackmore · 2025
Read Sox11 overexpression restores embryonic pro-growth transcription in mature corticospinal tract neurons by Elizabeth Batsel, Zimei Wang, Elizabeth Otten, Syed Roshan, Rabia Mohammad, Paula Pascual, Darby O’Shea, Jose Rosas, Pantelis Tsoulfas, Murray G. Blackmore (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12834943.txt.
Description
Elizabeth Batsel and co-authors show in 2025 that a single growth gene can wake up the growth program in adult nerve cells. Young nerve cells grow their long fibers well, but mature cells lose that power, which blocks repair after spinal injury. The gene, Sox11, fades as cells mature.
Forcing the gene back on in mature mouse tract cells reshaped their gene activity on a large scale. The new pattern closely matched that of young, pre-connection cells and stayed stable over time. The switch worked just as well in cells hurt long before. The work names a potent lever for future repair research.
Catalog record
| CREATOR | Elizabeth Batsel, Zimei Wang, Elizabeth Otten, Syed Roshan, Rabia Mohammad, Paula Pascual, Darby O’Shea, Jose Rosas, Pantelis Tsoulfas, Murray G. Blackmore |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |