A pan-cancer analysis of the oncogenic role of KIF13A in human tumors
Shangke Huang, Jizhang Chen, Yongxia Cui · 2025
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Description
Shangke Huang, Jizhang Chen, and Yongxia Cui scan a motor protein gene across thirty-three cancers. Their study is from two thousand twenty-five. The gene, called KIF13A, helps move cargo inside cells. Signs had tied it to cancer before, but no broad survey across cancer types had been done with public data.
In most tumors, the gene was less active than in healthy tissue. Yet its level tied to patient outcomes in ways that differed by cancer type. One uterine cancer with gene changes fared better than those without. Chemical tags on the gene also differed between tumors and nearby healthy tissue. Immune cell patterns linked to the gene ran in both directions across cancers. The authors present it as a possible marker and drug target.
Catalog record
| CREATOR | Shangke Huang, Jizhang Chen, Yongxia Cui |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |